San Francisco 49ers running back Isaac Guerendo (hamstring) was looking like a sure-fire league-winner after a highly impressive performance in Week 14. He carried the ball 15 times for 78 yards and two touchdowns and caught both his targets for 50 receiving yards in the blowout win.

RB Jordan Mason filled in admirably to start the year, but he was hit with a shoulder injury in Week 6 that he battled until McCaffrey’s return in Week 10. McCaffrey and Mason were both hurt in a Week 13 loss to the Buffalo Bills, which pushed rookie fourth-round pick RB Isaac Guerendo into the starting role.

San Francisco 49ers running back Isaac Guerendo appeared on Wednesday's injury report due to a hamstring issue sustained during last week's game against