"Certain parts of that movie ... will stay with me forever in a way that feels horrific. But I mean that in a good way," Qualley tells IndieWire.

The actress, who stars alongside Demi Moore in the body horror film, says it took "probably a year" for her skin to recover.

What was not particularly intended to be a box office blockbuster has become very much so, and both the Maid actress and her co-star Demi Moore have enjoyed plenty of awards season buzz, with the latter earning her first major Hollywood award after over 40 years in the industry.

Adhesive materials, artificial skin, and layers of heavy makeup used to create these effects can often clog pores

In an interview on the podcast Happy Sad Confused, actress Margaret Qualley shared that the prosthetics she wore for the movie "The Substance" caused her face to break out in "absurd" acne.

The actress spoke about dealing with acne caused by the movie makeup on Josh Horowitz's 'Happy Sad Confused' podcast

In The Substance, Hollywood star Elisabeth Sparkle (Demi Moore) is fired from her aerobics show when she turns 50. This leads her to seek out a drug called The Substance. After taking the drug, Elisabeth births a younger version of herself who she shares a consciousness with - the catch is she has to alternate living as each every seven days.

Margaret Qualley says her skin went through a lot while filming 'The Substance.' On Josh Horowitz’s 'Happy Sad Confused' podcast, the actress opened up about the effects of wearing prosthetics for the film and how it impacted her skin.

While Margaret Qualley has garnered high praise for her performance in 2024’s The Substance, she has revealed that the extensive amount of prosthetics that were required for the film took a toll on her skin.