The 49ers lost defensive tackle Javon Hargrave early with a torn triceps. Middle linebacker Fred Warner has played with an ankle fracture. Running mate Dre Greenlaw didn’t come back until Week 15, and now may be done for the year. Safety Talanoa Hufanga has attempted to rebound from a torn ACL, an ankle sprain and then wrist surgery.

The 49ers just lost 29-17 to the Miami Dolphins. Here are the 49ers' grades for this performance. QUARTERBACK: C Brock Purdy played well until the final two minutes of the game. That's when he needed to lead a touchdown drive in 2 minutes and 10 seconds with his team down by 5 points.

Kader Kohou left his feet for a game-sealing interception, helping the Miami Dolphins preserve a late lead over the San Francisco 49ers and keeping their razor-thin playoff hopes alive Sunday at Hard Rock Stadium.