Duke Watson, a fellow true freshman, took the lead running back role against Stanford in the wake of Brown's injury. He finished with 11 carries for 117 yards and three touchdowns. He became the first true freshman in Louisville history to rush for 100-plus yards and three touchdowns in a single game.

Louisville standout running back Isaac Brown was ruled out after the first half of the No. 24 Cardinals' game against host Stanford on Saturday because of a shoulder contusion, the Louisville Courier-Journal reported.

Louisville freshman running back Isaac Brown suffered a shoulder contusion and was ruled out after the first half Saturday against Stanford.