Ruled out Friday were left tackle Trent Williams (for the fifth straight game) and running back Isaac Guerendo (hamstring, foot; started two previous games). Defensive end Robert Beal Jr. (ankle) is also out, as are tight end Jake Tonges, defensive tackle Khalil Davis, and cornerback Rock Ya-Sin; Josh Dobbs is the No. 3 emergency quarterback.

San Francisco 49ers linebacker Dre Greenlaw and defensive lineman Nick Bosa are active for the team's Week 16 matchup vs. the Miami Dolphins after entering the weekend as questionable.

The San Francisco 49ers will once again be without Trent Williams and will also be minus rookie running back Isaac Guerendo for their Week 16 matchup with the Miami Dolphins, but there is still a chance they could have Nick Bosa available for a South Florida homecoming.

There was a chance the 49ers could've avoided De'Vondre Campbell's dramatics against the Rams. On Monday, Nick Bosa revealed it wasn't surprising to see Campbe

Bosa is officially active against the Rams, via Ian Rapoport of the NFL Network. Joining him are running back Isaac Guerendo and Dre Greenlaw. While injuries have dismantled San Francisco throughout the season, all three returns will be massive for their hopes against Los Angeles.

Bosa on Monday shared strong opinions about the 49ers defense and coordinator Nick Sorensen — he wants the status quo in 2025.

On Monday in the 49ers locker room, Nick Bosa was asked about De'Vondre Campbell quitting on the team. Here's what Bosa said. Q: Did you guys see

San Francisco 49ers defensive end Nick Bosa, listed as questionable for Thursday night's primetime matchup against the Los Angeles Rams, is likely to

Matos, Jake Tonges and more San Francisco 49ers players talked holiday characters as teammates, shared their favorite festive songs, dream holiday vacations and more.