Thrice is a red flag, a coach’s challenge on the legitimacy of the defending NFC champs.” Shanahan details 49ers’ next-day ...

When RB Kyle Juszczyk and the San Francisco 49ers clash with the Green Bay Packers in Week 12 on Sunday at 4:25 PM ET, they ...

The 49ers expect tight end George Kittle to practice Wednesday and cornerback Charvarius Ward has returned to the team and will be evaluated in hopes of returning in Week 12 to face the Buffalo Bills.

The San Francisco 49ers got a taste of what their defense looks like without Nick Bosa in the second half of a loss to ...

The injury-prone San Francisco 49ers are monitoring yet another health issue, this one involving quarterback Brock Purdy's ...

If it wasn't clear before the Week 11 loss to the Seattle Seahawks, it is definitely clear now. The San Francisco 49ers are hungover from their Super Bowl loss ...

Meanwhile, Harbaugh is in Los Angeles, coaching the Chargers to a 7-3 record, with quarterback Justin Herbert looking like a superstar. And the reigning college national champion is bringing the quirk ...

Star pass-catcher Jayden Reed and the Green Bay Packers play the San Francisco 49ers on Sunday at 4:25 p.m. ET, at Lambeau ...

One of the best pass-catchers in the NFL will be on show when Trey McBride and the Arizona Cardinals visit the Seattle ...

After falling to 5-5 with a disappointing 20-17 loss to the Seattle Seahawks on Sunday, the San Francisco 49ers received even ...

What are the lines we're looking at before movement later in the week? Here are some early picks for Week 12 of the NFL and ...

The breakdowns in the San Francisco 49ers' crushing loss to the Seattle Seahawks can be found in their PFF grades.