Our current model of NE rupture is that disorganization of the nuclear lamina leads to areas of weak membrane that are prone to both chromatin herniation and membrane rupture when force is applied to ...
It also anchors chromatin to the nuclear lamina through Lamin A/C. Here, the authors present cryo-EM structures of BAF-Lamin A/C-nucleosome complexes. STX16 microdeletions cause ...
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