Six teams are road favorites and two more are slight underdogs in Week 10. The 49ers, Bills, Vikings, Falcons, Eagles and ...

Detroit Lions lead with impressive odds in the NFC, outpacing the SF 49ers and Eagles. Jared Goff excels in top-scoring offense, Lions excel against the spread.

Matthew Berry, Connor Rogers, and Lawrence Jackson share their top bets ahead of the NFL's Week 10 slate, including the 49ers ...

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The San Francisco 49ers (4-4) had a bye last week, but their chances of making the playoffs increased to 50 percent. The table below represents the 49ers’ remaining games. Pick a winner and see what ...

The San Francisco 49ers could be getting their best player back on the field. Running back Christian McCaffrey returned to ...

I’m not sure why he would be willing to cut the 49ers any slack.” But “this level of play,” is an important caveat. After two ...

NFL Week 10 odds, picks, predictions, TV and streaming information for Sunday football game between San Francisco 49ers and ...

You could make the argument that the 49ers’ luck turned for the worse with 9:16 to go in the second quarter in Super Bowl ...

After an injury-plagued, shaky first half of the season for the defending NFC champion San Francisco 49ers, the team is hoping to follow a similar pattern to the past two seasons.

After contract disputes, key injuries and up-and-down play, the 49ers were 4-4 during their bye week and fighting for a chance to get back to the postseason.

SANTA CLARA, Calif. — You win some, you lose some. You win four, you lose four. Now nine games remain for the San Francisco 49ers to reach the playoffs as the reigning NFC champions. They should make ...